Pathophysiological relevance of mitochondria in NAD(+) metabolism

FEBS Lett. 2001 Mar 9;492(1-2):4-8. doi: 10.1016/s0014-5793(01)02198-6.


Pyridine nucleotides are mostly stored within mitochondria where they are involved in different functions ranging from energy metabolism to cellular signaling. Here we discuss the mechanisms of mitochondrial NAD(+) metabolism and release that may contribute to the crucial roles played by these organelles as triggers or amplifiers of physiological and pathological events.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis
  • Humans
  • Mitochondria, Heart / metabolism*
  • Myocardial Ischemia / metabolism
  • NAD / metabolism*
  • NADP / metabolism
  • Signal Transduction


  • NAD
  • NADP