DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

Curr Opin Cell Biol. 2001 Apr;13(2):225-31. doi: 10.1016/s0955-0674(00)00201-5.

Abstract

The DNA damage signalling pathway is a core element of the cellular response to genotoxic insult, and its components play key roles in defending against neoplastic transformation. Recent work has indicated that the human ATM and ATR proteins, and their yeast homologues, are intimately involved in sensing DNA damage, suggesting parallels with the DNA double-strand break repair enzyme DNA-PK.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins / metabolism*
  • DNA Damage*
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins / metabolism
  • Histones / metabolism
  • Humans
  • Nuclear Proteins
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction
  • Tumor Suppressor Proteins

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Histones
  • Nuclear Proteins
  • Tumor Suppressor Proteins
  • ATM protein, human
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • DNA-Activated Protein Kinase
  • PRKDC protein, human
  • Protein-Serine-Threonine Kinases