The Role of the Cdk5--p35 Kinase in Neuronal Development

Eur J Biochem. 2001 Mar;268(6):1528-33.


Cyclin-dependent kinase 5 (Cdk5) plays a key role in proper development of the nervous system. To be activated, Cdk5 associates with regulatory subunits not related to cyclins, such as p35 (the regulatory subunit of Cdk5). In this article, we review some of the experimental evidence supporting a central role for the Cdk5/p35 kinase in neuronal migration and process formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclin-Dependent Kinase 5
  • Cyclin-Dependent Kinases / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Neurons / cytology
  • Neurons / enzymology*


  • Nerve Tissue Proteins
  • neuronal Cdk5 activator (p25-p35)
  • Cyclin-Dependent Kinase 5
  • Cyclin-Dependent Kinases