Homeostasis of alpha beta TCR+ T cells

Nat Immunol. 2000 Aug;1(2):107-11. doi: 10.1038/77778.


Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type I cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytokines / immunology
  • Cytokines / metabolism*
  • Homeostasis
  • Humans
  • Immunologic Memory / immunology
  • Interleukin-2 / immunology
  • Interleukin-2 / metabolism
  • Lymphocyte Activation / immunology
  • Lymphocyte Count
  • Receptors, Antigen, T-Cell, alpha-beta*
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / immunology


  • Cytokines
  • Interleukin-2
  • Receptors, Antigen, T-Cell, alpha-beta