Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients

T Holm; A K Andreassen; T Ueland; J Kjekshus; S S Frøland; E Kjekshus; S Simonsen; P Aukrust; L Gullestad

doi:10.1016/s0002-9149(00)01516-2

Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients

Am J Cardiol. 2001 Mar 15;87(6):815-8, A9. doi: 10.1016/s0002-9149(00)01516-2.

Authors

T Holm¹, A K Andreassen, T Ueland, J Kjekshus, S S Frøland, E Kjekshus, S Simonsen, P Aukrust, L Gullestad

Affiliation

¹ Department of Cardiology, Research Institute for Internal Medicine, University of Oslo, Rikshospitalet, Norway. torbjorn.holm@klinmed.uio.no

PMID: 11249916
DOI: 10.1016/s0002-9149(00)01516-2

Abstract

Statins appear to have several biologic effects beyond those of lipid metabolism, and we hypothesized that immunomodulating effects of statins are important for the beneficial effects of these medications after heart transplantation. Our findings suggest that pravastatin treatment reduces plasma markers of inflammation and improves peripheral endothelial function in heart transplant recipients, possibly contributing to the observed clinical benefits of statin treatment in these patients.

Publication types

Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Cell Adhesion Molecules / blood
Cross-Over Studies
Cytokines / blood
Endothelium, Vascular / drug effects
Endothelium, Vascular / physiology*
Heart Transplantation*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Inflammation Mediators / blood*
Male
Microcirculation / drug effects
Middle Aged
Pilot Projects
Pravastatin / therapeutic use*
Skin / blood supply
Tumor Necrosis Factor-alpha / analysis
Vasodilation / drug effects*

Substances

Cell Adhesion Molecules
Cytokines
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Inflammation Mediators
Tumor Necrosis Factor-alpha
Pravastatin