Virulence genes in the pathogenic yeast Candida albicans

FEMS Microbiol Rev. 2001 Apr;25(2):245-68. doi: 10.1111/j.1574-6976.2001.tb00577.x.


In recent years, the incidence of fungal infections has been rising all over the world. Although the amount of research in the field of pathogenic fungi has also increased, there is still a need for the identification of reliable determinants of virulence. In this review, we focus on identified Candida albicans genes whose deletant strains have been tested in experimental virulence assays. We discuss the putative relationship of these genes to virulence and also outline the use of new different systems to examine the precise effect in virulence of different genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Candida albicans / genetics*
  • Candida albicans / pathogenicity
  • Cell Wall / chemistry
  • Cell Wall / metabolism
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Genes, Fungal*
  • Humans
  • Signal Transduction
  • Transcription, Genetic
  • Virulence / genetics


  • Fungal Proteins