Chromatin remodeling in development and differentiation

Curr Opin Genet Dev. 2001 Apr;11(2):167-74. doi: 10.1016/s0959-437x(00)00175-1.

Abstract

During development and differentiation, early inductive processes that influence cell fate at a later stage leave marks at distinct gene loci that are maintained through several rounds of mitosis. The structure of chromatin is part of this epigenetic memory that restricts or permits differential expression of genes in descendant cells. Establishing a cell-type-specific chromatin pattern thus predestines future cell differentiation and deters cell-lineage infidelity, as it often occurs during neoplastic transformation. As such, understanding the dynamics and mechanisms underlying chromatin remodeling has been a major focus of recent molecular genetic research that holds great promise for biomedical discoveries.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cell Lineage
  • Chromatin / genetics
  • Chromatin / metabolism*
  • Chromatin / ultrastructure*
  • Gene Expression Regulation*
  • Gene Expression Regulation, Developmental
  • Hematopoiesis
  • Humans
  • Leukemia / genetics
  • Leukemia / metabolism

Substances

  • Chromatin