RNA-based silencing strategies in plants

Curr Opin Genet Dev. 2001 Apr;11(2):221-7. doi: 10.1016/s0959-437x(00)00183-0.


In plants, double-stranded RNA can silence genes by triggering degradation of homologous RNA in the cytoplasm and by directing methylation of homologous nuclear DNA sequences. Analyses of Arabidopsis mutants and plant viral suppressors of silencing are unraveling RNA-silencing mechanisms, which require common proteins in diverse organisms, and are assessing the role of methylation in transcriptional and posttranscriptional gene silencing.

Publication types

  • Review

MeSH terms

  • Arabidopsis / genetics*
  • Arabidopsis / metabolism
  • DNA Methylation
  • DNA, Plant / metabolism
  • Gene Silencing*
  • Promoter Regions, Genetic
  • RNA, Antisense
  • RNA, Double-Stranded / metabolism
  • RNA, Messenger / biosynthesis
  • RNA, Plant / metabolism*
  • Transcription, Genetic


  • DNA, Plant
  • RNA, Antisense
  • RNA, Double-Stranded
  • RNA, Messenger
  • RNA, Plant