Molecular motors: Kinesin's string variable

Curr Biol. 2001 Feb 20;11(4):R147-9. doi: 10.1016/s0960-9822(01)00064-1.


A recent model suggests that the walking action of kinesin is due to a 13 residue 'fundamental engine' called the neck linker domain, which cyclically zips and unzips to the main part of the heads. New experiments confirm one prediction of the model: that crosslinking the neck linker to the head should block motility.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Adenylyl Imidodiphosphate / metabolism
  • Amino Acid Sequence
  • Animals
  • Humans
  • Kinesin / chemistry
  • Kinesin / metabolism*
  • Molecular Sequence Data
  • Structure-Activity Relationship


  • Adenylyl Imidodiphosphate
  • Adenosine Triphosphate
  • Kinesin