Tyrosine kinase signalling in breast cancer: fibroblast growth factors and their receptors

Breast Cancer Res. 2000;2(3):191-6. doi: 10.1186/bcr53. Epub 2000 Mar 25.


The fibroblast growth factors [Fgfs (murine), FGFs (human)] constitute a large family of ligands that signal through a class of cell-surface tyrosine kinase receptors. Fgf signalling has been associated in vitro with cellular differentiation as well as mitogenic and motogenic responses. In vivo, Fgfs are critical for animal development, and some have potent angiogenic properties. Several Fgfs have been identified as oncogenes in murine mammary cancer, where their deregulation is associated with proviral insertions of the mouse mammary tumour virus (MMTV). Thus, in some mammary tumours of MMTV-infected mouse strains, integration of viral genomic DNA into the somatic DNA of mammary epithelial cells was found to have caused the inappropriate expression of members of this family of growth factors. Although examination of human breast cancers has shown an altered expression of FGFs or of their receptors in some tumours, their role in the causation of breast disease is unclear and remains controversial.

Publication types

  • Review

MeSH terms

  • Animals
  • Breast / anatomy & histology
  • Breast / growth & development
  • Breast / physiology
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism*
  • Female
  • Fibroblast Growth Factors / genetics
  • Fibroblast Growth Factors / metabolism*
  • Humans
  • Mammary Tumor Virus, Mouse / genetics
  • Mammary Tumor Virus, Mouse / physiology
  • Mice
  • Oncogenes
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Fibroblast Growth Factor / genetics
  • Receptors, Fibroblast Growth Factor / metabolism
  • Signal Transduction*


  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors
  • Protein-Tyrosine Kinases