Human papillomavirus and p53 protein immunoreactivity in condylomata acuminatum and squamous cell carcinoma of penis

Asian J Androl. 2001 Mar;3(1):75-7.


Aim: To determine the immunoreactive pattern of human papillomavirus (HPV) antigen and p53 protein in condylomata acuminatum (CA) and squamous cell carcinoma (SCC) of penis.

Methods: Immunohistochemistry for HPV and p53 were performed in 40 specimens of formalin fixed, paraffin embedded tissues using a polyclonal (rabbit) antibody against HPV and a monoclonal (mouse) antibody against human p53 protein. Twenty one cases of CA and nineteen cases of SCC were examined.

Results: HPV antigen was detected in all 21 CA and 2 penile SCC. p53 protein overexpression was observed in 12 of 19 (63%) SCC in which 6 cases were strong positive. Five of 21 CA (24%) showed low-grade p53 protein overexpression.

Conclusion: CA is related to HPV infection and some cases show p53 protein low-grade overexpression. In contrast, p53 protein overexpression is common in penile SCC, which is seldom related to HPV infection.

MeSH terms

  • Carcinoma, Squamous Cell / metabolism
  • Carcinoma, Squamous Cell / virology*
  • Condylomata Acuminata / metabolism*
  • Condylomata Acuminata / virology
  • Humans
  • Immunohistochemistry
  • Male
  • Papillomaviridae / isolation & purification
  • Penile Neoplasms / metabolism
  • Penile Neoplasms / virology*
  • Tumor Suppressor Protein p53 / metabolism*
  • Tumor Virus Infections / metabolism*
  • Tumor Virus Infections / virology


  • Tumor Suppressor Protein p53