Abstract
Gacyclidine, a channel blocker of N-methyl-D-aspartate receptors (NMDAR), exhibits potent neuroprotective properties and a low self-neurotoxicity. Preventing its interaction with NMDARs we demonstrate, through the use of its enantiomers, that gacyclidine also interacts with other ('non-NMDA') binding sites. The autoradiographic study showed that these sites displayed a uniform specific binding in the forebrain and a more discrete distribution in the molecular layer of the cerebellum. The 'non-NMDA' binding sites could exert a modulatory control on glutamatergic neurotransmission.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Autoradiography
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Binding Sites / drug effects
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Brain Chemistry / drug effects*
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Cerebellum / chemistry
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Cerebellum / metabolism
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Cyclohexanes / chemistry
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Cyclohexanes / pharmacology*
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Cyclohexenes
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Dizocilpine Maleate / pharmacology
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Excitatory Amino Acid Antagonists / chemistry
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Excitatory Amino Acid Antagonists / pharmacology*
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Glutamic Acid / pharmacology
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Glycine / pharmacology
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Male
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Piperidines / chemistry
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Piperidines / pharmacology*
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Rats
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Rats, Wistar
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Receptors, N-Methyl-D-Aspartate / metabolism*
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Stereoisomerism
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Tritium
Substances
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Cyclohexanes
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Cyclohexenes
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Excitatory Amino Acid Antagonists
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Piperidines
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Receptors, N-Methyl-D-Aspartate
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Tritium
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Glutamic Acid
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Dizocilpine Maleate
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gacyclidine
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Glycine