Regulation of interleukin-12 production by G-protein-coupled receptors

Microbes Infect. 2001 Feb;3(2):99-107. doi: 10.1016/s1286-4579(00)01357-5.


G-protein-coupled receptors have long been known to play a critical role in the recruitment and migration of leukocytes to areas of inflammation. This review will focus, however, on emerging data that G-protein-coupled receptors can modulate cytokine production by antigen-presenting cells including interleukin-12 and tumor necrosis factor-alpha and may therefore play a significant role in the regulation of innate and acquired immunity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cyclic AMP / metabolism
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Gene Expression Regulation
  • Heterotrimeric GTP-Binding Proteins / metabolism*
  • Humans
  • Interleukin-12 / biosynthesis*
  • Interleukin-12 / genetics
  • Mice
  • Monocytes / immunology
  • Monocytes / metabolism
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction*


  • Receptors, Cell Surface
  • Interleukin-12
  • Cyclic AMP
  • Heterotrimeric GTP-Binding Proteins