P300 in Behcet's patients without neurological manifestations

Can J Neurol Sci. 2001 Feb;28(1):66-9. doi: 10.1017/s0317167100052586.

Abstract

Objective: Behcet's disease is the association of recurrent aphthous stomatitis with genital ulceration and eye disease. Neurologic involvement patterns include meningomyelitis, a brain stem syndrome, pyramidal and extrapyramidal abnormality and stroke. In the present study, subclinical involvement was investigated by using P300 in Behcet's patients without neurological manifestation.

Methods: Fifteen patients and 15 healthy volunteers were accepted for the study. P300 from vertex (Cz) electrode sites of the 10-20 system using electrodes and motor response time were recorded.

Results: Patients had significantly prolonged latencies of P300 as compared to normal controls (p=0.013) but no significant differences in amplitude (p=1.000). Patients showed a significantly delayed motor response time than controls (p=0.006). Nine patients (60%) had P300 latency and eight patients (53.3%) had motor response time values exceeding the mean of controls by two standard deviations.

Conclusion: The findings suggest that the P300 measures and motor response time may reflect subclinical neurologic involvement in Behcet's disease.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Behcet Syndrome / physiopathology*
  • Event-Related Potentials, P300 / physiology*
  • Evoked Potentials, Auditory, Brain Stem / physiology
  • Evoked Potentials, Motor / physiology
  • Female
  • Humans
  • Male
  • Middle Aged