Neurogenesis in the adult brain: death of a dogma

Nat Rev Neurosci. 2000 Oct;1(1):67-73. doi: 10.1038/35036235.


For over 100 years a central assumption in the field of neuroscience has been that new neurons are not added to the adult mammalian brain. This perspective examines the origins of this dogma, its perseverance in the face of contradictory evidence, and its final collapse. The acceptance of adult neurogenesis may be part of a contemporary paradigm shift in our view of the plasticity and stability of the adult brain.

Publication types

  • Review

MeSH terms

  • Adult
  • Animals
  • Brain / growth & development*
  • Cell Death / physiology
  • Cell Division / physiology
  • Cerebral Cortex / growth & development
  • Dentate Gyrus / growth & development
  • Humans
  • Learning / physiology*
  • Neuronal Plasticity
  • Neurons / physiology*