Estrogen, progesterone, and mood

J Gend Specif Med. 1999 Jan-Feb;2(1):29-36.


This article provides an overview of the literature on the role of estrogen and progesterone in modulating mood in women. The evidence that severe PMS is causally related to an ovarian hormone disorder is assessed. The influence of endogenous levels of estrogen and progesterone and of exogenously administered ovarian hormones on mood is evaluated.

Publication types

  • Review

MeSH terms

  • Affect / physiology
  • Depressive Disorder, Major / drug therapy
  • Estrogens / physiology*
  • Female
  • Humans
  • Ovary / physiology*
  • Premenstrual Syndrome / physiopathology*
  • Progesterone / physiology


  • Estrogens
  • Progesterone