How Cells Read TGF-beta Signals

Nat Rev Mol Cell Biol. 2000 Dec;1(3):169-78. doi: 10.1038/35043051.

Abstract

Cell proliferation, differentiation and death are controlled by a multitude of cell-cell signals, and loss of this control has devastating consequences. Prominent among these regulatory signals is the transforming growth factor-beta (TGF-beta) family of cytokines, which can trigger a bewildering diversity of responses, depending on the genetic makeup and environment of the target cell. What are the networks of cell-specific molecules that mould the TGF-beta response to each cell's needs?

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division
  • Humans
  • MAP Kinase Signaling System
  • Models, Biological
  • Receptors, Transforming Growth Factor beta / chemistry
  • Receptors, Transforming Growth Factor beta / physiology
  • Signal Transduction*
  • Transforming Growth Factor beta / chemistry
  • Transforming Growth Factor beta / physiology*

Substances

  • Receptors, Transforming Growth Factor beta
  • Transforming Growth Factor beta