The many substrates and functions of ATM

Nat Rev Mol Cell Biol. 2000 Dec;1(3):179-86. doi: 10.1038/35043058.


As its name suggests, the ATM--'ataxia-telangiectasia, mutated'--gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Ataxia Telangiectasia / diagnosis
  • Ataxia Telangiectasia / genetics
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle
  • Cell Cycle Proteins
  • DNA Damage
  • DNA Repair
  • DNA-Binding Proteins
  • Humans
  • Models, Biological
  • Molecular Sequence Data
  • Phenotype
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism*
  • Protein Serine-Threonine Kinases / physiology*
  • Sequence Homology, Amino Acid
  • Tumor Suppressor Proteins


  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Tumor Suppressor Proteins
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Protein Serine-Threonine Kinases