Three ways to make a vesicle

Nat Rev Mol Cell Biol. 2000 Dec;1(3):187-98. doi: 10.1038/35043117.


Cargo molecules have to be included in carrier vesicles of different forms and sizes to be transported between organelles. During this process, a limited set of proteins, including the coat proteins COPI, COPII and clathrin, carries out a programmed set of sequential interactions that lead to the budding of vesicles. A general model to explain the formation of coated vesicles is starting to emerge but the picture is more complex than we had imagined.

Publication types

  • Review

MeSH terms

  • Animals
  • COP-Coated Vesicles / physiology*
  • Cell Membrane / metabolism
  • Clathrin / chemistry
  • Clathrin / physiology*
  • Coat Protein Complex I / chemistry
  • Coat Protein Complex I / physiology*
  • Humans
  • Models, Biological
  • Transport Vesicles / physiology*


  • Clathrin
  • Coat Protein Complex I