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Review
, 2 (2), 107-17

Rab Proteins as Membrane Organizers

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Review

Rab Proteins as Membrane Organizers

M Zerial et al. Nat Rev Mol Cell Biol.

Erratum in

  • Nat Rev Mol Cell Biol 2001 Mar;2(3):216

Abstract

Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial distribution and communicate through an elaborate system of vesiculo-tubular transport. Rab proteins and their effectors coordinate consecutive stages of transport, such as vesicle formation, vesicle and organelle motility, and tethering of vesicles to their target compartment. These molecules are highly compartmentalized in organelle membranes, making them excellent candidates for determining transport specificity and organelle identity.

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