Filamins as integrators of cell mechanics and signalling

Nat Rev Mol Cell Biol. 2001 Feb;2(2):138-45. doi: 10.1038/35052082.


Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Membrane / physiology
  • Contractile Proteins / physiology*
  • Filamins
  • Microfilament Proteins / physiology*
  • Signal Transduction / physiology*


  • Contractile Proteins
  • Filamins
  • Microfilament Proteins