Interpretations of retrograde amnesia: old problems redux

Nat Rev Neurosci. 2001 Jan;2(1):68-70. doi: 10.1038/35049075.


Recent evidence indicates that an old memory reactivated by cueing becomes labile and vulnerable to an amnesic treatment. Although the 'reconsolidation' concept derived from these findings challenges the traditional consolidation theory, here we argue that the new concept suffers from some of the same limitations as the earlier model. We propose an alternative retrieval-based theory that accommodates the recent data, as well as other puzzling related observations.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amnesia, Retrograde / physiopathology*
  • Amnesia, Retrograde / psychology*
  • Amnesia, Retrograde / rehabilitation
  • Animals
  • Humans
  • Memory / physiology