Secrets of actin-based motility revealed by a bacterial pathogen

Nat Rev Mol Cell Biol. 2000 Nov;1(2):110-9. doi: 10.1038/35040061.


Actin-based cell motility is a complex process involving a dynamic, self-organizing cellular system. Experimental problems initially limited our understanding of this type of motility, but the use of a model system derived from a bacterial pathogen has led to a breakthrough. Now, all the molecular components necessary for dynamic actin self-organization and motility have been identified, setting the stage for future mechanistic studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / physiology*
  • Animals
  • Bacteria / pathogenicity
  • Bacterial Physiological Phenomena*
  • Cell Movement / physiology*
  • Humans
  • Listeria monocytogenes / physiology
  • Models, Biological
  • Movement / physiology*


  • Actins