Slow axonal transport: stop and go traffic in the axon

Nat Rev Mol Cell Biol. 2000 Nov;1(2):153-6. doi: 10.1038/35040102.


Efforts to observe the slow axonal transport of cytoskeletal polymers during the past decade have yielded conflicting results, and this has generated considerable controversy. The movement of neurofilaments has now been seen, and it is rapid, infrequent and highly asynchronous. This motile behaviour could explain why slow axonal transport has eluded observation for so long.

Publication types

  • Review

MeSH terms

  • Animals
  • Axonal Transport / physiology*
  • Axons / physiology*
  • Cytoskeletal Proteins / metabolism*
  • Cytoskeleton / physiology
  • Models, Neurological
  • Neurons / physiology


  • Cytoskeletal Proteins