Cadherins in embryonic and neural morphogenesis

Nat Rev Mol Cell Biol. 2000 Nov;1(2):91-100. doi: 10.1038/35040042.


Cadherins not only maintain the structural integrity of cells and tissues but also control a wide array of cellular behaviours. They are instrumental for cell and tissue polarization, and they regulate cell movements such as cell sorting, cell migration and cell rearrangements. Cadherins may also contribute to neurite outgrowth and pathfinding, and to synaptic specificity and modulation in the central nervous system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cadherins / genetics
  • Cadherins / physiology*
  • Cell Adhesion
  • Central Nervous System / embryology
  • Central Nervous System / physiology*
  • Embryonic and Fetal Development
  • Humans
  • Molecular Sequence Data
  • Morphogenesis*
  • Nervous System / cytology
  • Nervous System / embryology*
  • Protein Structure, Secondary
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Synapses / physiology


  • Cadherins