Mobile elements and the human genome

Nat Rev Genet. 2000 Nov;1(2):134-44. doi: 10.1038/35038572.

Abstract

Genomic DNA is often thought of as the stable template of heredity, largely dormant and unchanging, apart from perhaps the occasional point mutation. But it has become increasingly clear that DNA is dynamic rather than static, being subjected to rearrangements, insertions and deletions. Much of this plasticity can be attributed to transposable elements and their genomic relatives.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biotechnology / methods
  • DNA / genetics
  • DNA Transposable Elements
  • Genome, Human*
  • Humans
  • Interspersed Repetitive Sequences / genetics*
  • Sequence Deletion

Substances

  • DNA Transposable Elements
  • DNA