Cytokine levels in serum of patients with juvenile rheumatoid arthritis

Clin Rheumatol. 2001;20(1):30-5. doi: 10.1007/s100670170100.


We investigated serum levels of interleukin (IL)-1beta, IL-6, IL-8, IL-12 and tumour necrosis factor (TNF)-alpha in JRA patients during both active and inactive phases of the disease. The systemic JRA patients had the highest IL-1beta and IL-6 levels during both active and inactive periods. In the systemic group IL-1beta, IL-6 and IL-12 levels during the active period were elevated compared to the inactive period (p = 0.0173, p = 0.0359 and p = 0.0117, respectively). Levels of these cytokines during the inactive stage were still greater than those of controls. IL-8 and TNF-alpha levels during both active and inactive periods were comparable to controls. IL-1beta correlated strongly with CRP and ESR (p = 0.008 and p = 0.031, respectively). IL-6 correlated significantly with CRP (p = 0.002). IL-12 levels were found to be correlated with ESR and CRP (p = 0.03 and p = 0.04, respectively). In active polyarticular JRA patients, IL-6 levels were elevated compared to the inactive phase, and the control (p = 0.001) IL-12 levels decreased significantly with clinical remission (p = 0.018). There was a strong correlation between 11-12 levels and number of joint with limited motion (p = 0). In oligoarticular JRA patients, IL-12 levels during active period were greater than in the controls and there was a marked decrease in IL-12 levels when the patients entered the inactive phase (p = 0.001) In conclusion, IL-1beta, IL-6 and IL-12 may play an important role in JRA and may be used as a marker of disease activity.

MeSH terms

  • Adolescent
  • Arthritis, Juvenile / blood*
  • Arthritis, Juvenile / pathology
  • Child
  • Child, Preschool
  • Cytokines / blood*
  • Evaluation Studies as Topic
  • Female
  • Follow-Up Studies
  • Humans
  • Interleukin-1 / blood
  • Interleukin-12 / blood
  • Interleukin-6 / blood
  • Interleukin-8 / blood
  • Male
  • Statistics as Topic
  • Statistics, Nonparametric
  • Tumor Necrosis Factor-alpha / analysis


  • Cytokines
  • Interleukin-1
  • Interleukin-6
  • Interleukin-8
  • Tumor Necrosis Factor-alpha
  • Interleukin-12