Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood

JAMA. 2001 Mar 14;285(10):1316-21. doi: 10.1001/jama.285.10.1316.

Abstract

Context: Hospital-based studies have found that increased susceptibility to certain infections is associated with low serum levels of mannose-binding lectin (MBL) due to MBL variant alleles. However, the contribution of MBL insufficiency to incidence of common childhood infections at a population level is unknown.

Objective: To investigate the effect of MBL insufficiency on risk for acute respiratory tract infection (ARI) in unselected children younger than 2 years.

Design and setting: Population-based, prospective, cohort study conducted in Sisimiut, Greenland.

Participants: Two hundred fifty-two children younger than 2 years who were followed up weekly between August 1996 and August 1998 for morbidity surveillance.

Main outcome measure: Risk of ARI, based on medical history and clinical examination, compared by MBL genotype, determined from blood samples based on presence of structural and promoter alleles.

Results: A 2.08-fold (95% confidence interval [CI], 1.41-3.06) increased relative risk (RR) of ARI was found in MBL-insufficient children (n = 13) compared with MBL-sufficient children (n = 239; P<.001). The risk association was largely restricted to children aged 6 to 17 months (RR, 2.92; 95% CI, 1.78-4.79) while less effect (RR, 1.47; 95% CI, 0.45-4.82) and no effect (RR, 1.00; 95% CI, 0.42-2.37) was shown among children aged 0 to 5 months and 18 to 23 months, respectively.

Conclusion: These data suggest that genetic factors such as MBL insufficiency play an important role in host defense, particularly during the vulnerable period of childhood from age 6 through 17 months, when the adaptive immune system is immature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Alleles
  • Asian Continental Ancestry Group / genetics
  • Carrier Proteins / blood*
  • Carrier Proteins / genetics
  • European Continental Ancestry Group / genetics
  • Female
  • Genotype
  • Greenland / epidemiology
  • Humans
  • Infant
  • Inuits / genetics
  • Male
  • Mannose-Binding Lectins
  • Prospective Studies
  • Respiratory Tract Infections / blood*
  • Respiratory Tract Infections / epidemiology*
  • Risk Factors

Substances

  • Carrier Proteins
  • Mannose-Binding Lectins