Eph receptors and neural plasticity

Nat Rev Neurosci. 2001 Mar;2(3):205-9. doi: 10.1038/35058582.


Eph receptor tyrosine kinases are largely known for their involvement in brain development but, as some of these receptor tyrosine kinases are also expressed in adults, their possible role in the mature nervous system has begun to be explored. Evidence for the involvement of Eph receptors in synaptic plasticity, learning and memory is only emerging and needs corroboration. However, it is likely that the actions of Eph kinases in the adult brain will attract significant attention and become a fertile research area, as occurred in the case of the neurotrophins.

MeSH terms

  • Animals
  • Brain / physiology*
  • Brain Injuries / metabolism
  • Conditioning, Psychological
  • Ephrin-A5
  • Maze Learning
  • Membrane Proteins / immunology
  • Membrane Proteins / pharmacology
  • Mice
  • Neuronal Plasticity / physiology*
  • Neurons / metabolism*
  • Rats
  • Receptor Protein-Tyrosine Kinases / chemistry
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Receptor, EphA1
  • Synapses / physiology*


  • Ephrin-A5
  • Membrane Proteins
  • Receptor Protein-Tyrosine Kinases
  • Receptor, EphA1