Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats

Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):637-40. doi: 10.1358/mf.2000.22.8.802276.


The effect of treatment with the acute GABAA receptor agonist THIP and the GABAB receptor agonist baclofen on apomorphine-induced aggressive behavior was studied in adult male Wistar rats. Both THIP (10 mg/kg i.p.) and baclofen (8 mg/kg i.p.) attenuated the aggressiveness, thereby indicating the involvement of GABAergic neurotransmission in the mediation of apomorphine-induced aggressiveness. On the basis of our data it can be proposed that both GABAA and GABAB receptor subtypes are involved in the neurobiology of apomorphine-induced aggressive behavior, as this phenomenon is evidently subject to the general inhibitory effect of GABAergic neurotransmission.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggression / drug effects*
  • Aggression / physiology
  • Animals
  • Apomorphine
  • Baclofen / pharmacology*
  • Behavior, Animal / drug effects*
  • Behavior, Animal / physiology
  • Disease Models, Animal
  • GABA Agonists / pharmacology*
  • Isoxazoles / pharmacology*
  • Male
  • Neurotransmitter Agents / biosynthesis
  • Neurotransmitter Agents / physiology
  • Psychotic Disorders / physiopathology
  • Rats
  • Rats, Wistar
  • Receptors, GABA-A / drug effects
  • Receptors, GABA-B / drug effects
  • Synaptic Transmission / drug effects*


  • GABA Agonists
  • Isoxazoles
  • Neurotransmitter Agents
  • Receptors, GABA-A
  • Receptors, GABA-B
  • Baclofen
  • gaboxadol
  • Apomorphine