Progress in vaccination against Helicobacter pylori

Vaccine. 2001 Mar 21;19(17-19):2286-90. doi: 10.1016/s0264-410x(00)00518-1.

Abstract

This review discusses recent progress in the development of a vaccine against Helicobacter pylori. This progress includes demonstration that: effective immunisation is independent of antibodies but dependent upon CD4+ T helper cells, although their role remains unknown; the immunisation regime can be improved to increase efficacy; successful immunisation against H. pylori is possible using a live vector; a strain of H. pylori suitable for experimental infection of humans has been developed. Important issues that remain to be addressed include incomplete protection, non-availability of suitable mucosal adjuvants and post-immunisation gastritis. Significantly, commercial development of products for clinical trial is underway.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Animals
  • Bacterial Vaccines / administration & dosage
  • Bacterial Vaccines / adverse effects
  • Bacterial Vaccines / isolation & purification
  • Bacterial Vaccines / pharmacology
  • Gastritis / etiology
  • Helicobacter Infections / immunology
  • Helicobacter Infections / prevention & control*
  • Helicobacter pylori / immunology*
  • Humans
  • Immunity, Mucosal
  • Vaccination / adverse effects
  • Vaccination / trends

Substances

  • Adjuvants, Immunologic
  • Bacterial Vaccines