Therapeutic vaccines against melanoma and colorectal cancer

Vaccine. 2001 Mar 21;19(17-19):2571-5. doi: 10.1016/s0264-410x(00)00491-6.


Our overall strategy is to develop multivalent recombinant vaccines capable of eliciting broad immune responses in patients with malignant melanoma or colorectal cancer. We report herein results from initial studies conducted in cancer patients to evaluate the effect of intratumoral administration of recombinant canarypox viruses carrying cytokine genes. Our current focus is on the induction of tumor-specific T-cell responses using a prime/boost immunization schedule with a unique vector system derived from the canary pox virus called ALVAC, in which we incorporate genes encoding Tumor Associated Antigens (TAAs) of interest. Clinical studies in colorectal cancer evaluating an ALVAC CEA candidate vaccine have shown that this approach is safe and can induce tumor-specific T cell responses. Additional clinical studies evaluating candidate vaccines against melanoma and colorectal cancer, targeting either the gp100, Mage 1, Mage 3 or p53 molecules are ongoing.

Publication types

  • Review

MeSH terms

  • Antigens, Neoplasm / genetics
  • Avipoxvirus / genetics
  • Cancer Vaccines / genetics
  • Cancer Vaccines / immunology
  • Cancer Vaccines / therapeutic use*
  • Clinical Trials as Topic
  • Colorectal Neoplasms / immunology
  • Colorectal Neoplasms / therapy*
  • Cytokines / genetics
  • Genetic Vectors
  • Humans
  • Melanoma / immunology
  • Melanoma / therapy*
  • Safety
  • T-Lymphocytes / immunology
  • Vaccines, Synthetic / genetics
  • Vaccines, Synthetic / immunology
  • Vaccines, Synthetic / therapeutic use


  • Antigens, Neoplasm
  • Cancer Vaccines
  • Cytokines
  • Vaccines, Synthetic