Heat shock proteins: the 'Swiss Army Knife' vaccines against cancers and infectious agents

Vaccine. 2001 Mar 21;19(17-19):2590-7. doi: 10.1016/s0264-410x(00)00492-8.

Abstract

The ability of heat shock proteins to: (a) chaperone peptides, including antigenic peptides; (b) interact with antigen presenting cells through a receptor; (c) stimulate antigen presenting cells to secrete inflammatory cytokines; and (d) mediate maturation of dendritic cells, makes them a one-stop shop for the immune system. These properties also permit the utilization of heat shock proteins for development of a new generation of prophylactic and therapeutic vaccines against cancers and infectious diseases.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / therapeutic use
  • Animals
  • Antigen-Presenting Cells / immunology
  • Cancer Vaccines / immunology
  • Cancer Vaccines / isolation & purification*
  • Cancer Vaccines / pharmacology
  • Communicable Disease Control
  • Communicable Diseases / immunology*
  • Communicable Diseases / therapy
  • Heat-Shock Proteins / immunology*
  • Heat-Shock Proteins / therapeutic use*
  • Humans
  • Immunotherapy / methods
  • Necrosis
  • Neoplasms / immunology
  • Neoplasms / prevention & control
  • Neoplasms / therapy*

Substances

  • Adjuvants, Immunologic
  • Cancer Vaccines
  • Heat-Shock Proteins