Protein phosphatase 2A: the Trojan Horse of cellular signaling

Cell Signal. 2001 Jan;13(1):7-16. doi: 10.1016/s0898-6568(00)00123-6.


Dynamic phosphorylation and dephosphorylation of proteins are fundamental mechanisms utilized by cells to transduce signals. Whereas transduction by protein kinases has been a major focus of studies in the last decade, protein phosphatase 2A (PP2A) enzymes emerge in this millenium as the most fashionable players in cellular signaling. Viral proteins target specific PP2A enzymes in order to deregulate chosen cellular pathways in the host and promote viral progeny. The observation that a variety of viruses utilize PP2A to alienate cellular behavior emphasizes the fundamental importance of PP2A in signal transduction. This review will primarily focus on discussing the uniqueness of PP2A regulation and uncovering the critical role played by protein-protein interactions in the modulation of PP2A signaling. Moreover, the place of PP2A in signaling pathways and its functional significance for human diseases will be discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Microtubules / enzymology
  • Microtubules / ultrastructure
  • Neoplasms / enzymology
  • Neurodegenerative Diseases / enzymology
  • Parasitic Diseases / enzymology
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphoprotein Phosphatases / metabolism*
  • Protein Phosphatase 2
  • Protein Processing, Post-Translational / physiology
  • Protein Subunits
  • Signal Transduction / physiology*
  • Tissue Distribution / physiology
  • Virus Diseases / enzymology


  • Protein Subunits
  • Phosphatidylinositol 3-Kinases
  • Phosphoprotein Phosphatases
  • Protein Phosphatase 2