Longitudinal data analysis: an application to construction of a natural history profile of Duchenne muscular dystrophy

Neuromuscul Disord. 2001 Mar;11(2):165-70. doi: 10.1016/s0960-8966(00)00175-9.


A 30-month prospective study of 27 Scandinavian boys with confirmed diagnosis of Duchenne muscular dystrophy was carried out to construct profiles of the natural history of the disease. Assessments which included measures of voluntary muscle strength and function were done at 3 monthly intervals except for the first and second which were separated by 1 month. Recently developed statistical methods for analysis of longitudinal data with repeated observations on the same individual were used avoiding the problem of induced serial correlations. This allowed for the construction of both reference and prediction profiles for the variables %MRC, motor ability, walking time for 10 m and the sum of myometry of seven muscle groups.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Data Interpretation, Statistical
  • Disability Evaluation
  • Disease Progression
  • Humans
  • Linear Models
  • Longitudinal Studies
  • Male
  • Movement Disorders / etiology
  • Movement Disorders / pathology
  • Movement Disorders / physiopathology*
  • Muscle Weakness / etiology
  • Muscle Weakness / pathology
  • Muscle Weakness / physiopathology*
  • Muscle, Skeletal / pathology
  • Muscle, Skeletal / physiopathology*
  • Muscular Dystrophy, Duchenne / pathology
  • Muscular Dystrophy, Duchenne / physiopathology*
  • Prospective Studies