In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography

Drug Discov Today. 2001 Mar 1;6(6):293-302. doi: 10.1016/s1359-6446(01)01684-1.


Positron-emission tomography (PET) is a sensitive technique that can be used to measure drug pharmacokinetics and pharmacodynamics non-invasively in target tissues of patients. Here we focus on the application of this technology to address some of the bottlenecks in drug development, including: elucidation of pathophysiology, evaluation of pharmacokinetics, proof of principle of mechanism, and assessment of efficacy and/or response to therapy.