The labile nature of consolidation theory

Nat Rev Neurosci. 2000 Dec;1(3):216-9. doi: 10.1038/35044580.


'Consolidation' has been used to describe distinct but related processes. In considering the implications of our recent findings on the lability of reactivated fear memories, we view consolidation and reconsolidation in terms of molecular events taking place within neurons as opposed to interactions between brain regions. Our findings open up a new dimension in the study of memory consolidation. We argue that consolidation is not a one-time event, but instead is reiterated with subsequent activation of the memories.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amnesia / physiopathology
  • Animals
  • Brain / physiopathology*
  • Conditioning, Psychological / physiology
  • Humans
  • Memory / physiology*
  • Models, Neurological