Abstract
[structure: see text]. A new class of 3-hetero-13,14-dihydro prostaglandin F(1)(alpha) analogues was synthesized from a common intermediate. The latter was constructed via a two-step, three-component process. The lower chain, containing the 15-(phenoxymethyl) group, was synthesized in enantiopure form using Jacobsen's (salen)Co-catalyzed kinetic resolution of a terminal epoxide with phenol.
MeSH terms
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Animals
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COS Cells
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Glycine / chemistry
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Indicators and Reagents
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Prostaglandins F / chemical synthesis*
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Prostaglandins F / metabolism
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Prostaglandins F, Synthetic / chemical synthesis*
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Prostaglandins F, Synthetic / metabolism
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Receptors, Prostaglandin / metabolism
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Stereoisomerism
Substances
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Indicators and Reagents
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Prostaglandins F
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Prostaglandins F, Synthetic
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Receptors, Prostaglandin
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Glycine
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prostaglandin F1