An improved synthesis of chiral alpha-(4-bromobenzyl)alanine ethyl ester and its application to the synthesis of LFA-1 antagonist BIRT-377

J Org Chem. 2001 Mar 9;66(5):1903-5. doi: 10.1021/jo0013913.

Authors

S R Kapadia¹, D M Spero, M Eriksson

Affiliation

¹ Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, CT 06877, USA. skapadia@rdg.boehringer-ingelheim.com

PMID: 11262144
DOI: 10.1021/jo0013913

No abstract available

MeSH terms

Alanine / analogs & derivatives
Alanine / chemical synthesis*
Alanine / chemistry
Esters / chemical synthesis*
Esters / chemistry
Imidazoles / chemical synthesis*
Imidazoles / pharmacology
Imidazolidines*
Lymphocyte Function-Associated Antigen-1 / drug effects*
Magnetic Resonance Spectroscopy
Molecular Structure
Stereoisomerism

Substances

(4-bromobenzyl)alanine ethyl ester
BIRT 377
Esters
Imidazoles
Imidazolidines
Lymphocyte Function-Associated Antigen-1
Alanine