Metabolism of fluorine-containing drugs

Annu Rev Pharmacol Toxicol. 2001;41:443-70. doi: 10.1146/annurev.pharmtox.41.1.443.


This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fluorine Compounds / chemistry
  • Fluorine Compounds / metabolism*
  • Fluorine Compounds / pharmacokinetics
  • Humans
  • Pharmaceutical Preparations / metabolism*
  • Tissue Distribution


  • Fluorine Compounds
  • Pharmaceutical Preparations