Dialysis-related amyloidosis after renal transplantation

Semin Dial. Mar-Apr 2001;14(2):99-102. doi: 10.1046/j.1525-139x.2001.00038.x.

Abstract

There is no effective therapy for dialysis-related amyloidosis (DRA). The restoration of renal function with a functional graft seems the most reasonable therapy for this disturbing disease. Although there are not many prospective series on the efficacy of renal transplantation for DRA, all the studies agree that most of the patients experienced a significantly clinical improvement of the articular symptoms after a successful renal transplantation. Nevertheless, radiologic (bone cysts) and histologic lesions did not disappear after long-term follow-up.

Publication types

  • Review

MeSH terms

  • Amyloid / metabolism
  • Amyloidosis / etiology*
  • Amyloidosis / metabolism
  • Bone Cysts / diagnostic imaging
  • Bone Cysts / etiology
  • Humans
  • Immunohistochemistry
  • Kidney Transplantation*
  • Radiography
  • Renal Dialysis / adverse effects*
  • beta 2-Microglobulin / blood
  • beta 2-Microglobulin / metabolism

Substances

  • Amyloid
  • beta 2-Microglobulin