Antigen processing by the proteasome

Nat Rev Mol Cell Biol. 2001 Mar;2(3):179-87. doi: 10.1038/35056572.


The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes--the waste-disposal units of the cell--typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?

Publication types

  • Review

MeSH terms

  • Antigen Presentation*
  • Antigens / metabolism*
  • Cysteine Endopeptidases / chemistry
  • Cysteine Endopeptidases / immunology
  • Cysteine Endopeptidases / metabolism*
  • Models, Molecular
  • Multienzyme Complexes / chemistry
  • Multienzyme Complexes / immunology
  • Multienzyme Complexes / metabolism*
  • Proteasome Endopeptidase Complex
  • Ubiquitins / chemistry


  • Antigens
  • Multienzyme Complexes
  • Ubiquitins
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex