Review
doi: 10.1038/35056572.
Antigen processing by the proteasome
Affiliations
- PMID: 11265247
- DOI: 10.1038/35056572
Item in Clipboard
Review
Antigen processing by the proteasome
Nat Rev Mol Cell Biol.
2001 Mar.
Abstract
The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes--the waste-disposal units of the cell--typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?
Similar articles
-
The proteasome activator 11 S REG (PA28) and class I antigen presentation.Biochem J. 2000 Jan 1;345 Pt 1(Pt 1):1-15. Biochem J. 2000. PMID: 10600633 Free PMC article. Review.
-
Proteasome inhibitors and antigen presentation.Biopolymers. 1997;43(4):269-80. doi: 10.1002/(SICI)1097-0282(1997)43:4<269::AID-BIP2>3.0.CO;2-T. Biopolymers. 1997. PMID: 9316392 Review.
-
How antigenic peptides are made to fit their groove.Trends Biotechnol. 2001 Oct;19(10):378. doi: 10.1016/S0167-7799(01)01817-0. Trends Biotechnol. 2001. PMID: 11587741 No abstract available.
-
Proteasomes: destruction as a programme.Trends Biochem Sci. 1996 Mar;21(3):96-102. Trends Biochem Sci. 1996. PMID: 8882582 Review.
-
Post-proteasomal antigen processing for major histocompatibility complex class I presentation.Nat Immunol. 2004 Jul;5(7):670-7. doi: 10.1038/ni1089. Nat Immunol. 2004. PMID: 15224092 Review.
Cited by
-
Production of a Recombinant Dengue Virus 2 NS5 Protein and Potential Use as a Vaccine Antigen.Clin Vaccine Immunol. 2016 Jun 6;23(6):460-469. doi: 10.1128/CVI.00081-16. Print 2016 Jun. Clin Vaccine Immunol. 2016. PMID: 27030586 Free PMC article.
-
ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.J Immunol. 2013 Aug 15;191(4):1547-55. doi: 10.4049/jimmunol.1301043. Epub 2013 Jul 17. J Immunol. 2013. PMID: 23863903 Free PMC article.
-
A ubiquitin-proteasome system-related signature to predict prognosis, immune infiltration, and therapy efficacy for breast cancer.Immunol Res. 2024 Jun;72(3):368-382. doi: 10.1007/s12026-023-09440-x. Epub 2023 Dec 1. Immunol Res. 2024. PMID: 38036900
-
IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response.Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9241-6. doi: 10.1073/pnas.0501711102. Epub 2005 Jun 8. Proc Natl Acad Sci U S A. 2005. PMID: 15944226 Free PMC article.
-
APOBEC3G Regulation of the Evolutionary Race Between Adaptive Immunity and Viral Immune Escape Is Deeply Imprinted in the HIV Genome.Front Immunol. 2019 Jan 11;9:3032. doi: 10.3389/fimmu.2018.03032. eCollection 2018. Front Immunol. 2019. PMID: 30687306 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
