SUMO, ubiquitin's mysterious cousin

Nat Rev Mol Cell Biol. 2001 Mar;2(3):202-10. doi: 10.1038/35056591.

Abstract

Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO regulates various cellular processes, such as nuclear transport, signal transduction, stress response and cell-cycle progression. But, in contrast to ubiquitylation, sumoylation does not tag proteins for degradation, but seems to enhance their stability or modulate their subcellular compartmentalization.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Ligases / metabolism
  • Molecular Sequence Data
  • Proteins / metabolism
  • SUMO-1 Protein
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Sequence Homology, Amino Acid
  • Ubiquitin-Conjugating Enzymes*
  • Ubiquitins / genetics
  • Ubiquitins / metabolism*

Substances

  • Proteins
  • SUMO-1 Protein
  • Ubiquitins
  • Ubiquitin-Conjugating Enzymes
  • Ligases
  • ubiquitin-conjugating enzyme UBC9