Early detection of heart transplant patients with increased risk of ciclosporin nephrotoxicity

Lancet. 2001 Mar 17;357(9259):856-7. doi: 10.1016/S0140-6736(00)04207-0.


Chronic nephrotoxic effects from ciclosporin are a common clinical complication after heart transplantation and frequently lead to progressive renal failure. There is no laboratory test to predict development of chronic renal failure in heart transplant patients. We analysed urinary retinol-binding protein (uRBP) concentration, to assess proximal tubular dysfunction, in 36 clinically stable heart transplant patients. We detected a subgroup of 13 patients who had high concentrations of uRBP, good renal function, and a high risk of developing progressive renal failure compared with patients with normal uRBP (relative risk 3.87, p=0.003).

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cyclosporine / adverse effects*
  • Female
  • Heart Transplantation*
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Kidney Failure, Chronic / chemically induced*
  • Kidney Failure, Chronic / urine
  • Male
  • Middle Aged
  • Retinol-Binding Proteins / urine
  • Risk Factors
  • Survival Analysis


  • Immunosuppressive Agents
  • Retinol-Binding Proteins
  • Cyclosporine