Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells

Biochim Biophys Acta. 2001 Mar 19;1518(1-2):157-61. doi: 10.1016/s0167-4781(00)00289-x.


Herein we describe the isolation of a cDNA encoding a novel human Toll-like receptor (hTLR) that we term hTLR10. Human TLR10 contains 811 amino acid residues. Deduced amino acid sequence analysis reveals that like the other known hTLRs (hTLR1-9) it is characterized by a signal peptide followed by multiple leucine-rich repeats (LRRs), a cysteine-rich domain, a transmembrane sequence and a cytoplasmic domain homologous to that of the human interleukin-1 receptor. Phylogenetic analysis indicates that among all the hTLRs, hTLR10 is most closely related to hTLR1 and hTLR6; the overall amino acid identity is 50% and 49%, respectively. hTLR10 mRNA is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Expression analysis of cell lines indicates a predominance in a variety of immune cell types. Thus, hTLR10 is preferentially expressed in tissues and cells involved in immune responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Line
  • DNA, Complementary
  • Gene Expression
  • Humans
  • Lymph Nodes / metabolism
  • Molecular Sequence Data
  • Palatine Tonsil / metabolism
  • Receptors, Cell Surface / classification
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism
  • Sequence Homology, Amino Acid
  • Spleen / metabolism
  • Thymus Gland / metabolism
  • Toll-Like Receptor 10


  • DNA, Complementary
  • Receptors, Cell Surface
  • TLR10 protein, human
  • Toll-Like Receptor 10

Associated data

  • GENBANK/AF296673