Neonatal outcome of spontaneous and assisted twin pregnancies

Eur J Obstet Gynecol Reprod Biol. 2001 Mar;95(1):68-72. doi: 10.1016/s0301-2115(00)00372-9.


Objectives: Over the last 10 years, diffusion of assisted reproduction techniques (ovarian stimulation, IVF, GIFT) has led to an increased incidence of multiple pregnancies and consequently, of the related obstetric-neonatal problems. In this study, multiple births have been studied, with particular reference to the twin births occurring in the Gemelli hospital, Rome. The hospital is also a reference centre for obstetric pathologies and infertility treatment. In particular, attention has been focused on neonatal outcome, comparing twins born from spontaneous and assisted pregnancies.

Study design: 228 neonates from spontaneous twin pregnancies and 32 from assisted twin pregnancies were taken into consideration with regard to: premature birth, low birth-weight, intrauterine growth retardation, weight discordance, Apgar score, major neonatal diseases, and mortality.

Results: Results showed a significant higher incidence of prematurity and low birth-weight, as well as a significant lower gestational age, occurring more frequently in twins resulting from assisted pregnancies than in twins from spontaneous pregnancies. Furthermore, the incidence of severe depression at birth and respiratory disease was significantly higher in twins from assisted pregnancies than in those from spontaneous pregnancies, despite similar gestational age and birth-weight.

MeSH terms

  • Apgar Score
  • Diseases in Twins / epidemiology*
  • Female
  • Fertilization in Vitro
  • Fetal Growth Retardation / epidemiology
  • Humans
  • Incidence
  • Infant, Newborn
  • Infant, Newborn, Diseases / epidemiology*
  • Infant, Premature
  • Infant, Premature, Diseases / epidemiology
  • Italy / epidemiology
  • Longitudinal Studies
  • Pregnancy
  • Reproductive Techniques*
  • Twins / statistics & numerical data*