Quality of life and well-being of patients with myasthenia gravis

Muscle Nerve. 2001 Apr;24(4):512-6. doi: 10.1002/mus.1034.


The cardinal symptom of myasthenia gravis (MG) is weakness of voluntary muscles, a feature that may restrict full participation in life activities. In turn, such limitations may negatively affect quality of life (QOL) and well-being among individuals with the disease. In the present study, we administered a measure of QOL to 27 patients with generalized MG. Results revealed that functional status was negatively impacted in the domains of physical functioning, energy, and general health. However, a clinically meaningful difference was evident only on perceived ability to accomplish physical tasks. The results suggest that although MG requires accommodations in physical activities, general QOL and well-being does not differ markedly from the general population.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Affect
  • Aged
  • Depression / complications
  • Depression / diagnosis
  • Humans
  • Middle Aged
  • Myasthenia Gravis / complications
  • Myasthenia Gravis / diagnosis*
  • Myasthenia Gravis / physiopathology*
  • Neuropsychological Tests
  • Predictive Value of Tests
  • Quality of Life*
  • Regression Analysis
  • Reproducibility of Results
  • Severity of Illness Index