Guard cell abscisic acid signalling and engineering drought hardiness in plants

Nature. 2001 Mar 15;410(6826):327-30. doi: 10.1038/35066500.


Guard cells are located in the epidermis of plant leaves, and in pairs surround stomatal pores. These control both the influx of CO2 as a raw material for photosynthesis and water loss from plants through transpiration to the atmosphere. Guard cells have become a highly developed system for dissecting early signal transduction mechanisms in plants. In response to drought, plants synthesize the hormone abscisic acid, which triggers closing of stomata, thus reducing water loss. Recently, central regulators of guard cell abscisic acid signalling have been discovered. The molecular understanding of the guard cell signal transduction network opens possibilities for engineering stomatal responses to control CO2 intake and plant water loss.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Abscisic Acid / metabolism*
  • Animals
  • Arabidopsis
  • Calcium Channels / metabolism
  • Cloning, Molecular
  • Epidermis / metabolism
  • Lipid Metabolism
  • Phosphoric Monoester Hydrolases / metabolism
  • Plant Cells
  • Plant Structures / metabolism
  • Plants / genetics
  • Plants / metabolism*
  • Protein Kinases / metabolism
  • Second Messenger Systems
  • Signal Transduction*
  • Xenopus


  • Calcium Channels
  • Abscisic Acid
  • Protein Kinases
  • Phosphoric Monoester Hydrolases