Effect of athrombogenic therapy, especially high dose therapy of dipyridamole, after prosthetic valve replacement

J Cardiovasc Surg (Torino). Jan-Feb 1975;16(1):8-15.


In order to prevent thrombo-embolism after prosthetic valve replacement, a high dose therapy with 450 mg/day of Dipyridamole and 3,000 mg/day of Aspirin was carried out for 1 year and 2 months in 91 cases (26 cases with aortic valve replacement, 40 cases with mitral valve replacement and 25 cases with multiple valve replacement). In the treated group, the incidence was 1.9% in cases more than 5 years after valve replacement and 2.9% in cases less than 5 years after valve replacement. In contrast, in the control group of 89 cases (47 cases of aortic valve replacement, 30 cases of mitral valve replacement and 12 cases of multiple valve replacement), the incidence was 9.1% and 14.7%, respectively. Thus, in both time intervals following prosthetic valve replacement the incidence of thrombo-embolism in the treated group was significantly lower than in the control group.

MeSH terms

  • Aortic Valve / surgery
  • Blood Platelets / drug effects
  • Cell Survival / drug effects
  • Dipyridamole / administration & dosage*
  • Dipyridamole / adverse effects
  • Dipyridamole / therapeutic use
  • Drug Evaluation
  • Follow-Up Studies
  • Heart Valve Diseases / surgery*
  • Heart Valve Prosthesis / adverse effects*
  • Humans
  • Mitral Valve / surgery
  • Thromboembolism / prevention & control*


  • Dipyridamole