Pregnancy outcome in recurrent spontaneous abortion associated with antiphospholipid antibodies: a comparative study of intravenous immunoglobulin versus prednisone plus low-dose aspirin

Am J Reprod Immunol. 2001 Mar;45(3):174-9. doi: 10.1111/j.8755-8920.2001.450309.x.


Problem: To compare the use of intravenous immunoglobulins (IVIG) with prednisone plus low-dose aspirin (LDA) in treating pregnant women with a history of recurrent fetal loss having the antiphospholipid antibody (aPL), in terms of live-birth rate and maternal and perinatal morbidity.

Method: A prospective, two-centers trial study included 82 recurrent aborters with aPL syndrome. Twenty-nine were treated with prednisone and LDA in one center, 53 received IVIG in the other center. Maternal and fetal outcomes and pregnancy complications were compared between groups.

Results: Live-birth rates were equivalent between groups (78 vs 76%). Mean birth weight was higher in the IVIG group than in the prednisone plus LDA group. In the prednisone- plus LDA-treated patients, gestational hypertension and gestational diabetes were found significantly more often than in the IVIG-treated group (14 vs 5% and 14 vs 5%, respectively).

Conclusion: In patients with aPL syndrome, IVIG treatment improved pregnancy outcome, with significantly lower pregnancy complication rates, when compared with prednisone plus LDA therapy.

Publication types

  • Clinical Trial

MeSH terms

  • Abortion, Habitual / drug therapy*
  • Abortion, Habitual / immunology*
  • Adult
  • Antibodies, Antiphospholipid / blood*
  • Aspirin / therapeutic use*
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Prednisone / therapeutic use*
  • Pregnancy
  • Pregnancy Outcome


  • Antibodies, Antiphospholipid
  • Immunoglobulins, Intravenous
  • Aspirin
  • Prednisone